In this thesis, I focus on how DNA from the plague bacterium can be used to estimate where and when this disease appeared in the past. To do so, I reconstruct the evolutionary relationships between modern and ancient strains of plague, using publicly available data and new DNA sequences retrieved from the skeletal remains of plague victims in Denmark.
Efficient and comprehensive metadata acquisition from the NCBI databases.
Global spread and evolution of the plague bacterium, Yersinia pestis.
NCBImeta is a command-line application that downloads and organizes biological metadata from the National Centre for Biotechnology Information (NCBI).
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