Spyrou et al. 2016 Historical Pestis Genomes

Field	Value
Title	Historical Y. pestisYersinia pestis [[Yersinia pestis]] Phylogenetic Branches [[Branch]] [[Clade]] Subclade [[Branch 0]] [[0.ANT]] [[0.ANT1]]     [[0.ANT3]]     [[0.ANT4]]   [0.PRE] [[0.PRE1]]     [[0.PRE2]]   [[0.PE]] [[0.PE2]]     [[0.PE4]]     [[0.PE7]] [... genomes reveal the European Black Death as the source of ancientAncient Ancient and modern plaguePlague Plague Disease caused by the bacterium [[Yersinia pestis]]. pandemics.
Year	2016
Authors	Spyrou et al.
DOI	https://doi.org/10.1016/j.chom.2016.05.012
bibtex	spyrou2016HistoricalPestisGenomes

Summary

• The authors discuss the issue of Sampling Bias

  sampling bias in reconstructing the Geographic Origin

  geographic origins of both the first Emergence

  emergence of plague and the Black Death.

• They highlight the issue of the strong East Asia

  East Asian sampling bias, and attempt to alleviate this by incorporating Modern Yersinia pestis

  Y. pestis strains from the Caucasus.

• This paper could be a useful reference for Diagnostic SNP

  diagnostic SNPs.

Dialogue

• Spyrou et al. 2016 Historical Pestis Genomes

  Spyrou et al. (2016) discusses the analysis of Cui et al. 2013 Historical Variations Mutation

  Cui et al. (2013) and Morelli et al. 2010 Yersinia Pestis Genome

  Morelli et al. (2010) with regards to the Geographic Origin

  geographic origins of plague being in China. The authors argue that those findings may be influenced by a strong East Asia

  East Asian Sampling Bias. To additionally support their claim, they point to Cui et al. 2013 Historical Variations Mutation

  Cui et al. (2013) own findings that the most basally Divergence

  diverging Clade

  clades of PlaguePlague Plague Disease caused by the bacterium Yersinia pestisYersinia pestis [[Yersinia pestis]] Phylogenetic Branches [[Branch]] [[Clade]] Subclade [[Branch 0]] [[0.ANT]] [[0.ANT1]]     [[0.ANT3]]     [[0.ANT4]]   [0.PRE] [[0.PRE1]]     [[0.PRE2]]   [[0.PE]] [[0.PE2]]     [[0.PE4]]     [[0.PE7]] [.... are found in the Former Soviet Union, ie. the Caucasus.

• This paper integrates Caucasus Yersinia pestis

  Y. pestis strains from Zhgenti et al. 2015 Genome Assemblies 11

  Zhgenti et al. (2015),

Figures

Fig 3
!spyrou2016HistoricalPestisGenomes_fig3.jpg
Hypothesized dissemination of Y. pestisYersinia pestis [[Yersinia pestis]] Phylogenetic Branches [[Branch]] [[Clade]] Subclade [[Branch 0]] [[0.ANT]] [[0.ANT1]]     [[0.ANT3]]     [[0.ANT4]]   [0.PRE] [[0.PRE1]]     [[0.PRE2]]   [[0.PE]] [[0.PE2]]     [[0.PE4]]     [[0.PE7]] [... during the second and third pandemics.
Spyrou et al. (2016)

Tables

Table 1
!spyrou2016HistoricalPestisGenomes_table1.jpg
Diagnostic SNPs present in this study.
Spyrou et al. (2016)

Notes

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